{"id":3928,"date":"2018-10-23T16:06:00","date_gmt":"2018-10-23T07:06:00","guid":{"rendered":"https:\/\/www.genome.rcast.u-tokyo.ac.jp\/?p=3928"},"modified":"2020-05-31T09:15:40","modified_gmt":"2020-05-31T00:15:40","slug":"%e6%82%aa%e6%80%a7%e8%83%b8%e8%86%9c%e4%b8%ad%e7%9a%ae%e8%85%ab%e3%81%ae%e7%b5%b1%e5%90%88%e3%82%b2%e3%83%8e%e3%83%a0%e8%a7%a3%e6%9e%90","status":"publish","type":"post","link":"https:\/\/www.genome.rcast.u-tokyo.ac.jp\/en\/%e6%82%aa%e6%80%a7%e8%83%b8%e8%86%9c%e4%b8%ad%e7%9a%ae%e8%85%ab%e3%81%ae%e7%b5%b1%e5%90%88%e3%82%b2%e3%83%8e%e3%83%a0%e8%a7%a3%e6%9e%90\/","title":{"rendered":"\u60aa\u6027\u80f8\u819c\u4e2d\u76ae\u816b\u306e\u7d71\u5408\u30b2\u30ce\u30e0\u89e3\u6790"},"content":{"rendered":"\n

\u5f53\u7814\u7a76\u5ba4\u306e\u5927\u5b66\u9662\u751f\u306e\u7af9\u4e0b\u7d14\u5e73\u3001\u798f\u7530\u53f2\u6717\u7814\u7a76\u54e1\u3001\u8fb0\u91ce\u5065\u4e8c\u7814\u7a76\u54e1\u304a\u3088\u3073\u5c71\u672c\u5c1a\u543e\u7814\u7a76\u54e1\u306fThe Cancer Genome Atlas (TCGA)\u306e\u60aa\u6027\u80f8\u819c\u4e2d\u76ae\u816b\u306e\u30d7\u30ed\u30b8\u30a7\u30af\u30c8\u306b\u53c2\u52a0\u3057\u3066\u304d\u307e\u3057\u305f\u304c\u3001\u7d71\u5408\u30b2\u30ce\u30e0\u89e3\u6790\u306b\u95a2\u3059\u308b\u8ad6\u6587\u304c10\/15\u4ed8\u3051\u3067Cancer discovery\u8a8c\u306e\u30aa\u30f3\u30e9\u30a4\u30f3\u306b\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f\u3002\u672c\u7814\u7a76\u3067\u306f\u3001\u65e5\u672c\u4eba\u60aa\u6027\u80f8\u819c\u4e2d\u76ae\u816b\u3068TCGA\u306e\u5168\u30a8\u30af\u30bd\u30fc\u30e0\u89e3\u6790\u306e\u30c7\u30fc\u30bf\u3092\u6d3b\u7528\u3057\u3001\u60aa\u6027\u80f8\u819c\u4e2d\u76ae\u816b\u306b\u304a\u3044\u3066\u30b3\u30d4\u30fc\u6570\u304c\u307b\u307c1\u500d\u4f53\u3092\u793a\u3059 (near-haploidization)\u65b0\u305f\u306a\u4e9c\u578b\u306e\u540c\u5b9a\u306b\u8ca2\u732e\u3057\u307e\u3057\u305f\u3002\u3053\u306e\u4e9c\u578b\u306f\u3001\u5168\u75c7\u4f8b\u306b\u304a\u3044\u3066SETDB1\u907a\u4f1d\u5b50\u7570\u5e38\u3092\u6709\u3057\u3066\u304a\u308a\u3001\u5973\u6027\u306b\u591a\u3044\u3068\u3044\u3046\u7279\u5fb4\u304c\u3042\u308a\u3001\u5f93\u6765\u306e\u60aa\u6027\u80f8\u819c\u4e2d\u76ae\u816b(BAP1\u307e\u305f\u306fNF2\u907a\u4f1d\u5b50\u7570\u5e38\u3001\u7537\u6027\u306b\u591a\u3044)\u3068\u306f\u660e\u3089\u304b\u306b\u7570\u306a\u308b\u7279\u5fb4\u3092\u6709\u3057\u3066\u3044\u307e\u3057\u305f\u3002\u4eca\u56de\u306e\u7d71\u5408\u89e3\u6790\u306e\u7d50\u679c\u306f\u3001\u81e8\u5e8a\u5fdc\u7528\u304c\u9032\u3080\u304c\u3093\u30b2\u30ce\u30e0\u533b\u7642\u306e\u66f4\u306a\u308b\u9032\u5c55\u306b\u5bc4\u4e0e\u3059\u308b\u3082\u306e\u3068\u8003\u3048\u3089\u308c\u307e\u3057\u305f\u3002
<\/p>\n\n\n\n


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\"\"
Near haploidization (\u539f\u6587Figure3c)<\/figcaption><\/figure><\/div>\n\n\n\n

\u672c\u7814\u7a76\u306e\u65e5\u672c\u4eba\u60aa\u6027\u80f8\u819c\u4e2d\u76ae\u816b\u306e\u30c7\u30fc\u30bf\u306f\u3001\u611b\u77e5\u770c\u7acb\u304c\u3093\u30bb\u30f3\u30bf\u30fc\u5206\u5b50\u816b\u760d\u5b66\u5206\u91ce\u306e\u95a2\u6238\u597d\u5b5d\u5148\u751f\u3001\u5175\u5eab\u533b\u79d1\u5927\u5b66\u540d\u8a89\u6559\u6388\u306e\u4e2d\u91ce\u5b5d\u53f8\u5148\u751f\u3089\u3068\u306e\u5171\u540c\u7814\u7a76\u3067\u53ce\u96c6\u3057\u305f\u30c7\u30fc\u30bf\u30bb\u30c3\u30c8\u3092\u4f7f\u7528\u3057\u307e\u3057\u305f\u3002

<\/p>\n\n\n\n

\u96d1\u8a8c\u540d: Cancer discovery<\/p>\n\n\n\n

\u8ad6\u6587\u30bf\u30a4\u30c8\u30eb:Integrative Molecular Characterization of Malignant Pleural Mesothelioma<\/p>\n\n\n\n

\u30a6\u30a7\u30d6\u30b5\u30a4\u30c8:http:\/\/cancerdiscovery.aacrjournals.org\/content\/early\/2018\/10\/13\/2159-8290.CD-18-0804<\/a><\/p>\n\n\n","protected":false},"excerpt":{"rendered":"

\u5f53\u7814\u7a76\u5ba4\u306e\u5927\u5b66\u9662\u751f\u306e\u7af9\u4e0b\u7d14\u5e73\u3001\u798f\u7530\u53f2\u6717\u7814\u7a76\u54e1\u3001\u8fb0\u91ce\u5065\u4e8c\u7814\u7a76\u54e1\u304a\u3088\u3073\u5c71\u672c\u5c1a\u543e\u7814\u7a76\u54e1\u306fThe Cancer Genome Atlas (TCGA)\u306e\u60aa\u6027\u80f8\u819c\u4e2d\u76ae\u816b\u306e\u30d7\u30ed\u30b8\u30a7\u30af\u30c8\u306b\u53c2\u52a0\u3057\u3066\u304d\u307e\u3057\u305f\u304c\u3001\u7d71\u5408\u30b2\u30ce\u30e0\u89e3\u6790\u306b\u95a2\u3059\u308b\u8ad6\u6587 … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":54,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[16],"tags":[],"class_list":["post-3928","post","type-post","status-publish","format-standard","hentry","category-news"],"_links":{"self":[{"href":"https:\/\/www.genome.rcast.u-tokyo.ac.jp\/en\/wp-json\/wp\/v2\/posts\/3928","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.genome.rcast.u-tokyo.ac.jp\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.genome.rcast.u-tokyo.ac.jp\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.genome.rcast.u-tokyo.ac.jp\/en\/wp-json\/wp\/v2\/users\/54"}],"replies":[{"embeddable":true,"href":"https:\/\/www.genome.rcast.u-tokyo.ac.jp\/en\/wp-json\/wp\/v2\/comments?post=3928"}],"version-history":[{"count":4,"href":"https:\/\/www.genome.rcast.u-tokyo.ac.jp\/en\/wp-json\/wp\/v2\/posts\/3928\/revisions"}],"predecessor-version":[{"id":4323,"href":"https:\/\/www.genome.rcast.u-tokyo.ac.jp\/en\/wp-json\/wp\/v2\/posts\/3928\/revisions\/4323"}],"wp:attachment":[{"href":"https:\/\/www.genome.rcast.u-tokyo.ac.jp\/en\/wp-json\/wp\/v2\/media?parent=3928"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.genome.rcast.u-tokyo.ac.jp\/en\/wp-json\/wp\/v2\/categories?post=3928"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.genome.rcast.u-tokyo.ac.jp\/en\/wp-json\/wp\/v2\/tags?post=3928"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}