{"id":3939,"date":"2018-11-01T11:57:44","date_gmt":"2018-11-01T02:57:44","guid":{"rendered":"https:\/\/www.genome.rcast.u-tokyo.ac.jp\/?p=3939"},"modified":"2020-05-31T09:15:40","modified_gmt":"2020-05-31T00:15:40","slug":"%e3%82%b7%e3%83%b3%e3%82%b0%e3%83%ab%e3%82%bb%e3%83%ab%e8%a7%a3%e6%9e%90%e3%81%a8%e6%a9%9f%e6%a2%b0%e5%ad%a6%e7%bf%92%e3%81%ab%e3%82%88%e3%82%8a%e5%bf%83%e4%b8%8d%e5%85%a8%e7%99%ba%e7%97%87%e3%81%ae","status":"publish","type":"post","link":"https:\/\/www.genome.rcast.u-tokyo.ac.jp\/en\/%e3%82%b7%e3%83%b3%e3%82%b0%e3%83%ab%e3%82%bb%e3%83%ab%e8%a7%a3%e6%9e%90%e3%81%a8%e6%a9%9f%e6%a2%b0%e5%ad%a6%e7%bf%92%e3%81%ab%e3%82%88%e3%82%8a%e5%bf%83%e4%b8%8d%e5%85%a8%e7%99%ba%e7%97%87%e3%81%ae\/","title":{"rendered":"\u30b7\u30f3\u30b0\u30eb\u30bb\u30eb\u89e3\u6790\u3068\u6a5f\u68b0\u5b66\u7fd2\u306b\u3088\u308a\u5fc3\u4e0d\u5168\u767a\u75c7\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u89e3\u660e"},"content":{"rendered":"\n<p 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class=\"wp-block-paragraph\">\u3053\u306e\u554f\u984c\u3092\u89e3\u6c7a\u3059\u308b\u305f\u3081\u306b\u3001\u5354\u529b\u7814\u7a76\u54e1\u306e\u91ce\u6751\u5f81\u592a\u90ce\uff08\u6771\u4eac\u5927\u5b66\u533b\u5b66\u90e8\u9644\u5c5e\u75c5\u9662 \u5faa\u74b0\u5668\u5185\u79d1\uff09\u30fb\u4f50\u85e4\u771f\u6d0b\uff08\u5343\u8449\u5927\u5b66\u533b\u5b66\u90e8\u9644\u5c5e\u75c5\u9662 \u5faa\u74b0\u5668\u5185\u79d1\uff09\u3068\u7279\u4efb\u7814\u7a76\u54e1\u306e\u85e4\u7530\u9686\u6559\u306f\u30b7\u30f3\u30b0\u30eb\u30bb\u30ebRNA-seq\u89e3\u6790\uff08\u3072\u3068\u3064\u3072\u3068\u3064\u306e\u7d30\u80de\u306e\u5168\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u91cf\u3092\u5b9a\u91cf\u89e3\u6790\u3059\u308b\u624b\u6cd5\uff09\u3068\u6a5f\u68b0\u5b66\u7fd2\u3092\u7d44\u307f\u5408\u308f\u305b\u3066\u3001\u5fc3\u4e0d\u5168\u30e2\u30c7\u30eb\u30de\u30a6\u30b9\u3084\u5fc3\u4e0d\u5168\u60a3\u8005\u3055\u3093\u306e\u5fc3\u7b4b\u7d30\u80de\u306e\u72b6\u614b\u3092\u8abf\u3079\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u305d\u306e\u7d50\u679c\u5206\u304b\u3063\u305f\u3053\u3068\u306f\u4ee5\u4e0b\u306e3\u70b9\u3067\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>\u8ca0\u8377\u304c\u304b\u304b\u308b\u3068\u3001\u5fc3\u7b4b\u7d30\u80de\u306f\u80a5\u5927\u578b\u306e\u5fc3\u7b4b\u7d30\u80de\u306b\u306a\u308b\u3002<\/li><li>\u8ca0\u8377\u304c\u7d9a\u304f\u3068\u3001\u80a5\u5927\u578b\u5fc3\u7b4b\u7d30\u80de\u306f\u4ee3\u511f\u578b\u30fb\u4e0d\u5168\u578b\u3068\u3044\u30462\u7a2e\u985e\u306e\u5fc3\u7b4b\u7d30\u80de\u306b\u5206\u5c90\u3059\u308b<\/li><li>\u5206\u5c90\u70b9\u306b\u304a\u3044\u3066p53\u3068\u3044\u3046\u300c\u304c\u3093\u6291\u5236\u907a\u4f1d\u5b50\u300d\u304c\u6d3b\u6027\u5316\u3059\u308b\u3068\u4e0d\u5168\u578b\u306e\u5fc3\u7b4b\u7d30\u80de\u306b\u306a\u308b\u3002<\/li><\/ul>\n\n\n\n<figure class=\"wp-block-image\"><img loading=\"lazy\" decoding=\"async\" width=\"597\" height=\"358\" src=\"https:\/\/www.genome.rcast.u-tokyo.ac.jp\/wp-content\/uploads\/2018\/11\/795316b92fc766b0181f6fef074f03fa.png\" alt=\"\" class=\"wp-image-3940\" srcset=\"https:\/\/www.genome.rcast.u-tokyo.ac.jp\/wp-content\/uploads\/2018\/11\/795316b92fc766b0181f6fef074f03fa.png 597w, https:\/\/www.genome.rcast.u-tokyo.ac.jp\/wp-content\/uploads\/2018\/11\/795316b92fc766b0181f6fef074f03fa-300x180.png 300w\" sizes=\"auto, (max-width: 597px) 100vw, 597px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">\u4ee5\u4e0b\u306b\u8a73\u3057\u304f\u8aac\u660e\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>\u5fc3\u7b4b\u7d30\u80de\u306f\u7d21\u9318\u72b6\u306e\u5f62\u3092\u3057\u3066\u3044\u307e\u3059\u3002\u5fc3\u81d3\u306b\u8ca0\u8377\u304c\u304b\u304b\u308b\u3068\u5fc3\u7b4b\u7d30\u80de\u306f\u8ca0\u8377\u306b\u6253\u3061\u52dd\u3064\u305f\u3081\u306b\u80a5\u5927\uff08\u77ed\u5f84\u304c\u5897\u5927\u3057\u307e\u3059\uff09\u3059\u308b\u3068\u3068\u3082\u306b\u3001\u30dd\u30f3\u30d7\u6a5f\u80fd\u306e\u7dad\u6301\u306b\u5fc5\u8981\u306a\u30a8\u30cd\u30eb\u30ae\u30fc\u3092\u751f\u307f\u51fa\u3059\u305f\u3081\u306b\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\uff08\u5fc3\u7b4b\u7d30\u80de\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u306e\u6e90\u3067\u3042\u308bATP\u3092\u7523\u751f\u3059\u308b\u88c5\u7f6e\u3067\u3059\uff09\u3092\u305f\u304f\u3055\u3093\u4f5c\u308a\u307e\u3059\u3002<\/li><li>\u3057\u304b\u3057\u6162\u6027\u7684\u306b\u8ca0\u8377\u3092\u53d7\u3051\u7d9a\u3051\u308b\u3068\u3001\u80a5\u5927\u578b\u306e\u5fc3\u7b4b\u7d30\u80de\u306f\u4ee3\u511f\u578b\u3068\u4e0d\u5168\u578b\u3068\u3044\u30462\u7a2e\u985e\u306e\u5fc3\u7b4b\u7d30\u80de\u3078\u5206\u5c90\u3057\u307e\u3059\u3002\u4ee3\u511f\u578b\u306f\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u3092\u7dad\u6301\u3057\u3066\u30a8\u30cd\u30eb\u30ae\u30fc\u3092\u4fdd\u3063\u3066\u3044\u307e\u3059\u304c\u3001\u4e0d\u5168\u578b\u306f\u5341\u5206\u306a\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u3092\u4f5c\u308b\u3053\u3068\u304c\u3067\u304d\u305a\u306b\u30a8\u30cd\u30eb\u30ae\u30fc\u4e0d\u8db3\u3068\u306a\u308a\u80a5\u5927\u3067\u306f\u306a\u304f\u4f38\u3073\u304d\u3063\u305f\u30b4\u30e0\u306e\u3088\u3046\u306b\u4f38\u9577\u3057\u305f\u5f62\u306b\u306a\u3063\u3066\u3057\u307e\u3044\u307e\u3059\u3002<\/li><li>\u7279\u306b\u6162\u6027\u7684\u306a\u8ca0\u8377\u306b\u3088\u308ap53\u3068\u3044\u3046\u300c\u304c\u3093\u6291\u5236\u907a\u4f1d\u5b50\u300d\u304c\u5206\u5c90\u70b9\u306b\u304a\u3044\u3066\u6d3b\u6027\u5316\u3059\u308b\u3068\u4e0d\u5168\u578b\u306e\u5fc3\u7b4b\u7d30\u80de\u306b\u306a\u3063\u3066\u3057\u307e\u3044\u307e\u3059\u3002\u3053\u306e\u4e0d\u5168\u578b\u306e\u5fc3\u7b4b\u7d30\u80de\u304c\u591a\u304f\u306a\u308b\u3068\u5fc3\u4e0d\u5168\u3092\u767a\u75c7\u3057\u307e\u3059\u3002\u4e0d\u5168\u578b\u306e\u5fc3\u7b4b\u7d30\u80de\u3092\u591a\u304f\u6301\u3064\u60a3\u8005\u3055\u3093\u306f\u3001\u6cbb\u7642\u306b\u5bfe\u3057\u3066\u826f\u304f\u53cd\u5fdc\u3057\u306a\u3044\u3053\u3068\u3082\u308f\u304b\u308a\u307e\u3057\u305f\u3002<\/li><\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">\u3053\u308c\u3089\u306e\u6210\u679c\u306f\u3001\u5fc3\u4e0d\u5168\u767a\u75c7\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u660e\u3089\u304b\u306b\u3057\u305f\u3060\u3051\u3067\u306a\u304f\u3001\u3072\u3068\u308a\u3072\u3068\u308a\u306e\u5fc3\u4e0d\u5168\u60a3\u8005\u3055\u3093\u306e\u7279\u5fb4\u3092\u628a\u63e1\u3059\u308b\u65b0\u305f\u306a\u65b9\u6cd5\u3068\u3057\u3066\u6ce8\u76ee\u3055\u308c\u3001\u5fc3\u4e0d\u5168\u306e\u7cbe\u5bc6\u533b\u7642\uff08\u500b\u5225\u5316\u533b\u7642\uff09\u306e\u5b9f\u73fe\u306b\u8ca2\u732e\u3059\u308b\u3082\u306e\u3068\u3057\u3066\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u672c\u7814\u7a76\u306f\u672c\u5b66\u9644\u5c5e\u75c5\u9662 \u5faa\u74b0\u5668\u5185\u79d1\u306e\u5c0f\u5ba4\u4e00\u6210\u6559\u6388\u3068\u306e\u5171\u540c\u7814\u7a76\u306b\u3088\u308a\u884c\u308f\u308c\u305f\u3082\u306e\u3067\u3001\u82f1\u56fd\u306e\u79d1\u5b66\u96d1\u8a8c<em>Nature Communications<\/em>\u306b\u3066<a href=\"https:\/\/www.nature.com\/articles\/s41467-018-06639-7?utm_source=feedburner&amp;utm_medium=feed&amp;utm_campaign=Feed%3A+ncomms%2Frss%2Fcurrent+%28Nature+Communications+-+current%29\">\u516c\u958b<\/a>\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u96d1\u8a8c\u540d:&nbsp;<em>Nature Communications<\/em><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u8ad6\u6587\u30bf\u30a4\u30c8\u30eb: <a href=\"https:\/\/www.nature.com\/articles\/s41467-018-06639-7?utm_source=feedburner&amp;utm_medium=feed&amp;utm_campaign=Feed%3A+ncomms%2Frss%2Fcurrent+%28Nature+Communications+-+current%29\">Cardiomyocyte gene programs encoding morphological and functional signatures in cardiac hypertrophy and failure.<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u8457\u8005: Nomura S, Satoh M, Fujita T, Higo T, Sumida T, Ko T, Yamaguchi T, Tobita T, Naito AT, Ito M, Fujita K, Harada M, Toko H, Kobayashi Y, Ito K, Takimoto E, Akazawa H, Morita H, Aburatani H, Komuro I.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u5fc3\u4e0d\u5168\u306f\u304c\u3093\u3068\u4e26\u3093\u3067\u4e16\u754c\u4e2d\u3067\u591a\u304f\u306e\u60a3\u8005\u306e\u547d\u3092\u8105\u304b\u3059\u75be\u60a3\u3067\u3059\u3002\u5fc3\u81d3\u306b\u9ad8\u8840\u5727\u3084\u5f01\u819c\u75c7\uff08\u5fc3\u81d3\u306e\u5f01\u306e\u7570\u5e38\u306b\u3088\u308a\u5fc3\u81d3\u306e\u4e2d\u3067\u8840\u6db2\u306e\u9006\u6d41\u3084\u6e0b\u6ede\u304c\u751f\u3058\u308b\u75be\u60a3\uff09\u306e\u3088\u3046\u306a\u8ca0\u8377\u304c\u304b\u304b\u308b\u3068\u4ee3\u511f\u7684\u306b\u5fc3\u81d3\u306f\u80a5\u5927\u3057\u3066\u30dd\u30f3\u30d7\u6a5f\u80fd\u3092\u7dad\u6301\u3057\u3088\u3046\u3068\u3057\u307e\u3059\u304c\u3001 &hellip; <a href=\"https:\/\/www.genome.rcast.u-tokyo.ac.jp\/en\/%e3%82%b7%e3%83%b3%e3%82%b0%e3%83%ab%e3%82%bb%e3%83%ab%e8%a7%a3%e6%9e%90%e3%81%a8%e6%a9%9f%e6%a2%b0%e5%ad%a6%e7%bf%92%e3%81%ab%e3%82%88%e3%82%8a%e5%bf%83%e4%b8%8d%e5%85%a8%e7%99%ba%e7%97%87%e3%81%ae\/\">Continue reading <span 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