{"id":4096,"date":"2019-10-15T11:47:39","date_gmt":"2019-10-15T02:47:39","guid":{"rendered":"https:\/\/www.genome.rcast.u-tokyo.ac.jp\/?p=4096"},"modified":"2019-10-24T16:09:07","modified_gmt":"2019-10-24T07:09:07","slug":"b%e5%9e%8b%e8%82%9d%e7%82%8e%e3%82%a6%e3%82%a4%e3%83%ab%e3%82%b9%ef%bc%88hbv%ef%bc%89%e6%84%9f%e6%9f%93%e6%ad%b4%e3%81%ae%e3%81%82%e3%82%8b%e6%82%a3%e8%80%85%e3%81%a7%e3%81%ae%e8%82%9d%e7%b4%b0","status":"publish","type":"post","link":"https:\/\/www.genome.rcast.u-tokyo.ac.jp\/en\/b%e5%9e%8b%e8%82%9d%e7%82%8e%e3%82%a6%e3%82%a4%e3%83%ab%e3%82%b9%ef%bc%88hbv%ef%bc%89%e6%84%9f%e6%9f%93%e6%ad%b4%e3%81%ae%e3%81%82%e3%82%8b%e6%82%a3%e8%80%85%e3%81%a7%e3%81%ae%e8%82%9d%e7%b4%b0\/","title":{"rendered":"B\u578b\u809d\u708e\u30a6\u30a4\u30eb\u30b9\uff08HBV\uff09\u611f\u67d3\u6b74\u306e\u3042\u308b\u60a3\u8005\u3067\u306e\u809d\u7d30\u80de\u304c\u3093\u306e\u767a\u751f\u306b\u53ca\u307c\u30592\u578b\u30a2\u30c7\u30ce\u968f\u4f34\u30a6\u30a4\u30eb\u30b9\uff08AAV2\uff09\u304a\u3088\u3073HBV\u306e\u30b2\u30ce\u30e0\u3078\u306e\u7d44\u8fbc\u307f\u306e\u5f71\u97ff\u306e\u89e3\u660e"},"content":{"rendered":"\n

\u6162\u6027HBV\u611f\u67d3\u60a3\u8005\u3067\u306fB\u578b\u809d\u708e\u30a6\u30a4\u30eb\u30b9\uff08HBV\uff09\u306e\u809d\u7d30\u80de\u30b2\u30ce\u30e0\u3078\u306e\u7d44\u8fbc\u307f\u306f\u3001\u304c\u3093\u5316\u306e\u30c9\u30e9\u30a4\u30d0\u30fc\u3068\u306a\u308b\u907a\u4f1d\u5b50\u306e\u8ee2\u5199\u3092\u5909\u5316\u3055\u305b\u3001\u809d\u7d30\u80de\u304c\u3093\u306e\u767a\u75c7\u3078\u7e4b\u304c\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u304c\u3001HBV\u65e2\u611f\u67d3\u60a3\u8005\u3067\u306f\u30a6\u30a4\u30eb\u30b9\u306e\u95a2\u4e0e\u306b\u3064\u3044\u3066\u306f\u660e\u3089\u304b\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/p>\n

\u4eca\u56de\u3001\u30b2\u30ce\u30e0\u30b5\u30a4\u30a8\u30f3\u30b9\u5206\u91ce\u306e\u8fb0\u91ce\u5065\u4e8c\u3001\u6c38\u6c5f\u7384\u592a\u3001\u5c71\u672c\u5c1a\u543e\u3089\u306f\u65e5\u672c\u5927\u5b66\u533b\u5b66\u90e8\u6d88\u5316\u5668\u5916\u79d1\u306e\u7dd1\u5ddd\u6cf0\u51c6\u6559\u6388\u3001\u9ad8\u5c71\u5fe0\u5229\u6559\u6388\u3068\u306e\u5171\u540c\u7814\u7a76\u3067\u3001\u30a6\u30a4\u30eb\u30b9\u30ad\u30e3\u30d7\u30c1\u30e3\u30fc\u30b7\u30fc\u30b1\u30f3\u30b9\u6cd5\u306b\u3088\u308a\u30a6\u30a4\u30eb\u30b9\u30b2\u30ce\u30e0\u306e\u30b2\u30ce\u30e0\u3078\u306e\u7d44\u8fbc\u307f\u3092\u89e3\u6790\u3057\u307e\u3057\u305f\u3002HBV\u65e2\u611f\u67d3\u60a3\u8005\u306e\u809d\u7d30\u80de\u304c\u3093\u306b\u304a\u3044\u3066\u3082\u6162\u6027HBV\u611f\u67d3\u60a3\u8005\u3068\u540c\u69d8\u306bTERT\u3001KMT2B\u3001CCNA2<\/em>\u3001\u304a\u3088\u3073CCNE1<\/em>\u306a\u3069\u306e\u304c\u3093\u5316\u306e\u30c9\u30e9\u30a4\u30d0\u30fc\u907a\u4f1d\u5b50\u3078\u306e\u30a6\u30a4\u30eb\u30b9\u306e\u7d44\u8fbc\u307f\u304c\u8d77\u3053\u308a\u3001\u3053\u308c\u3089\u306e\u907a\u4f1d\u5b50\u306e\u8ee2\u5199\u3092\u6d3b\u6027\u5316\u3057\u3066\u3044\u308b\u75c7\u4f8b\u304c\u5c11\u306a\u304f\u306a\u3044\u3053\u3068\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u3002\u3053\u306e\u3053\u3068\u306f\u3001\u81ea\u7136\u9000\u7e2e\u307e\u305f\u306fB\u578b\u809d\u708e\u6cbb\u7642\u306b\u3088\u308aHBs\u6297\u539f\u304c\u8840\u6db2\u4e2d\u304b\u3089\u6d88\u5931\u3057\u305f\u306e\u3061\u306b\u304a\u3044\u3066\u3082\u3001\u4f9d\u7136\u3068\u3057\u3066\u809d\u7d30\u80de\u304c\u3093\u3092\u767a\u75c7\u3059\u308b\u30ea\u30b9\u30af\u304c\u3042\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002\u307e\u305f\u30a2\u30c7\u30ce\u968f\u4f34\u30a6\u30a4\u30eb\u30b9\u306f\u3001\u75c5\u539f\u6027\u3092\u6301\u305f\u306a\u3044\u30a6\u30a4\u30eb\u30b9\u3068\u8003\u3048\u3089\u308c\u3066\u304d\u307e\u3057\u305f\u304c\u3001\u8fd1\u5e74AAV2\u306e\u809d\u7d30\u80de\u304c\u3093\u30b2\u30ce\u30e0\u3078\u306e\u7d44\u8fbc\u307f\u304c\u809d\u304c\u3093\u306e1-2%\u7a0b\u5ea6\u3067\u898b\u3064\u304b\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u4eca\u56de\u306fAAV2\u306b\u5bfe\u3057\u3066\u3082\u30a6\u30a4\u30eb\u30b9\u30ad\u30e3\u30d7\u30c1\u30e3\u30fc\u30b7\u30fc\u30b1\u30f3\u30b9\u306b\u3088\u308b\u89e3\u6790\u3092\u5b9f\u65bd\u3057\u3001HBV\u3068\u540c\u69d8\u306b\u3001\u304c\u3093\u5316\u306e\u30c9\u30e9\u30a4\u30d0\u30fc\u907a\u4f1d\u5b50\u3067\u3042\u308bCCNE1, CCNA2<\/em>\u3078\u306e\u7d44\u8fbc\u307f\u304c\u8d77\u304d\u3001\u3053\u308c\u3089\u306e\u907a\u4f1d\u5b50\u306e\u8ee2\u5199\u3092\u6d3b\u6027\u5316\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u793a\u3057\u307e\u3057\u305f\u3002<\/p>\n

\"\"

\u56f3\uff1a\u30a6\u30a4\u30eb\u30b9\u304c\u7d44\u8fbc\u3080\u907a\u4f1d\u5b50\u306e\u5168\u4f53\u50cf<\/p><\/div>\n

\u00a0<\/p>\n

\u96d1\u8a8c\u540d\uff1aClinical Cancer Research\u3000<\/p>\n

\u8ad6\u6587\u30bf\u30a4\u30c8\u30eb\uff1aImpact of AAV2 and Hepatitis B Virus Integration Into Genome on Development of Hepatocellular Carcinoma in Patients with Prior Hepatitis B Virus Infection<\/a><\/p>\n

\u8457\u8005\uff1aKenji Tatsuno, Yutaka Midorikawa, Tadatoshi Takayama, Shogo Yamamoto, Genta Nagae, Mitsuhiko Moriyama, Hayato Nakagawa, Kazuhiko Koike, Kyoji Moriya and Hiroyuki Aburatani<\/p>\n

October 15 2019 25 (20) 6217-6227;\u00a0DOI:<\/span> 10.1158\/1078-0432.CCR-18-4041<\/p>\n","protected":false},"excerpt":{"rendered":"

\u6162\u6027HBV\u611f\u67d3\u60a3\u8005\u3067\u306fB\u578b\u809d\u708e\u30a6\u30a4\u30eb\u30b9\uff08HBV\uff09\u306e\u809d\u7d30\u80de\u30b2\u30ce\u30e0\u3078\u306e\u7d44\u8fbc\u307f\u306f\u3001\u304c\u3093\u5316\u306e\u30c9\u30e9\u30a4\u30d0\u30fc\u3068\u306a\u308b\u907a\u4f1d\u5b50\u306e\u8ee2\u5199\u3092\u5909\u5316\u3055\u305b\u3001\u809d\u7d30\u80de\u304c\u3093\u306e\u767a\u75c7\u3078\u7e4b\u304c\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u304c\u3001HBV\u65e2\u611f\u67d3\u60a3\u8005\u3067\u306f\u30a6\u30a4\u30eb\u30b9\u306e\u95a2\u4e0e\u306b\u3064\u3044\u3066\u306f\u660e\u3089 … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":54,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[16],"tags":[],"class_list":["post-4096","post","type-post","status-publish","format-standard","hentry","category-news"],"_links":{"self":[{"href":"https:\/\/www.genome.rcast.u-tokyo.ac.jp\/en\/wp-json\/wp\/v2\/posts\/4096","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.genome.rcast.u-tokyo.ac.jp\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.genome.rcast.u-tokyo.ac.jp\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.genome.rcast.u-tokyo.ac.jp\/en\/wp-json\/wp\/v2\/users\/54"}],"replies":[{"embeddable":true,"href":"https:\/\/www.genome.rcast.u-tokyo.ac.jp\/en\/wp-json\/wp\/v2\/comments?post=4096"}],"version-history":[{"count":8,"href":"https:\/\/www.genome.rcast.u-tokyo.ac.jp\/en\/wp-json\/wp\/v2\/posts\/4096\/revisions"}],"predecessor-version":[{"id":4119,"href":"https:\/\/www.genome.rcast.u-tokyo.ac.jp\/en\/wp-json\/wp\/v2\/posts\/4096\/revisions\/4119"}],"wp:attachment":[{"href":"https:\/\/www.genome.rcast.u-tokyo.ac.jp\/en\/wp-json\/wp\/v2\/media?parent=4096"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.genome.rcast.u-tokyo.ac.jp\/en\/wp-json\/wp\/v2\/categories?post=4096"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.genome.rcast.u-tokyo.ac.jp\/en\/wp-json\/wp\/v2\/tags?post=4096"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}