{"id":4140,"date":"2019-11-26T11:00:17","date_gmt":"2019-11-26T02:00:17","guid":{"rendered":"https:\/\/www.genome.rcast.u-tokyo.ac.jp\/?p=4140"},"modified":"2020-05-31T09:17:01","modified_gmt":"2020-05-31T00:17:01","slug":"%e5%bf%83%e4%b8%8d%e5%85%a8%e6%82%a3%e8%80%85%e3%81%ae%e6%b2%bb%e7%99%82%e5%bf%9c%e7%ad%94%e6%80%a7%e3%82%84%e4%ba%88%e5%be%8c%e3%82%92%e5%bf%83%e7%ad%8bdna%e6%90%8d%e5%82%b7%e3%81%ae%e7%a8%8b","status":"publish","type":"post","link":"https:\/\/www.genome.rcast.u-tokyo.ac.jp\/en\/%e5%bf%83%e4%b8%8d%e5%85%a8%e6%82%a3%e8%80%85%e3%81%ae%e6%b2%bb%e7%99%82%e5%bf%9c%e7%ad%94%e6%80%a7%e3%82%84%e4%ba%88%e5%be%8c%e3%82%92%e5%bf%83%e7%ad%8bdna%e6%90%8d%e5%82%b7%e3%81%ae%e7%a8%8b\/","title":{"rendered":"\u5fc3\u4e0d\u5168\u60a3\u8005\u306e\u6cbb\u7642\u5fdc\u7b54\u6027\u3084\u4e88\u5f8c\u3092\u5fc3\u7b4bDNA\u640d\u50b7\u306e\u7a0b\u5ea6\u3067\u4e88\u6e2c\u3067\u304d\u308b\u3053\u3068\u3092\u5b9f\u8a3c"},"content":{"rendered":"\n<p>\u3000\u5fc3\u4e0d\u5168\u306f\u3001\u3055\u307e\u3056\u307e\u306a\u539f\u56e0\u306b\u3088\u308a\u5fc3\u81d3\u306e\u6a5f\u80fd\u304c\u60aa\u304f\u306a\u308a\u3001\u606f\u5207\u308c\u3084\u3080\u304f\u307f\u304c\u751f\u3058\u3001\u304c\u3093\u3068\u4e26\u3093\u3067\u4e16\u754c\u4e2d\u306e\u4eba\u306e\u547d\u3092\u8105\u304b\u3059\u75c5\u6c17\u3067\u3059\u3002\u5fc3\u4e0d\u5168\u306e\u7d4c\u904e\u3084\u6cbb\u7642\u306b\u5bfe\u3059\u308b\u52b9\u679c\u306f\u975e\u5e38\u306b\u591a\u69d8\u3067\u3042\u308a\u3001\u6cbb\u7642\u304c\u594f\u52b9\u3057\u3066\u5fc3\u81d3\u306e\u6a5f\u80fd\u304c\u56de\u5fa9\u3059\u308b\u60a3\u8005\u304c\u3044\u308b\u4e00\u65b9\u3067\u3001\u3042\u3089\u3086\u308b\u6cbb\u7642\u3092\u5c3d\u304f\u3057\u3066\u3082\u5fc3\u81d3\u6a5f\u80fd\u304c\u56de\u5fa9\u305b\u305a\u306b\u65e9\u3044\u6bb5\u968e\u3067\u5fc3\u81d3\u79fb\u690d\u3092\u3057\u306a\u3051\u308c\u3070\u547d\u3092\u6551\u3046\u3053\u3068\u304c\u3067\u304d\u306a\u3044\u60a3\u8005\u3082\u3044\u307e\u3059\u3002\u3053\u306e\u3088\u3046\u306a\u6cbb\u7642\u306b\u5bfe\u3059\u308b\u52b9\u679c\u3084\u4e88\u5f8c\uff08\u75c5\u72b6\u306e\u7d4c\u904e\uff09\u3092\u6cbb\u7642\u524d\u306b\u4e88\u6e2c\u3067\u304d\u308c\u3070\u3001\u60a3\u8005\u4e00\u4eba\u3072\u3068\u308a\u306b\u5408\u3063\u305f\u9069\u5207\u306a\u6cbb\u7642\u3092\u65bd\u3059\u3053\u3068\u304c\u53ef\u80fd\u306b\u306a\u308b\uff08\u3053\u308c\u3092\u7cbe\u5bc6\u533b\u7642\u3068\u8a00\u3044\u307e\u3059\uff09\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u304c\u3001\u73fe\u6bb5\u968e\u3067\u306f\u307e\u3060\u7c21\u4fbf\u304b\u3064\u6b63\u78ba\u306b\u6cbb\u7642\u5fdc\u7b54\u6027\uff08\u85ac\u306b\u3088\u308b\u52b9\u679c\uff09\u3092\u4e88\u6e2c\u3059\u308b\u3053\u3068\u304c\u96e3\u3057\u3044\u305f\u3081\u3001\u57fa\u672c\u7684\u306b\u753b\u4e00\u7684\u306a\u6cbb\u7642\u3092\u65bd\u3059\u3057\u304b\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n<p>\u3000\u91ce\u6751\u5f81\u592a\u90ce\u7814\u7a76\u54e1\uff08\u6771\u4eac\u5927\u5b66\u533b\u5b66\u90e8\u9644\u5c5e\u75c5\u9662 \u5faa\u74b0\u5668\u5185\u79d1\u7279\u4efb\u52a9\u6559\uff09\u306f\u3001\u30de\u30a6\u30b9\u3092\u7528\u3044\u305f\u5fc3\u4e0d\u5168\u306e\u75c5\u614b\u89e3\u660e\u7814\u7a76\u306b\u3088\u308a\u3001\u5fc3\u4e0d\u5168\u306b\u306a\u308b\u3068\u5fc3\u81d3\u306b\u3042\u308b\u5fc3\u7b4b\u7d30\u80de\u306e\u6838\u306e\u4e2d\u306eDNA\u306b\u30ad\u30ba\u304c\u751f\u3058\uff08DNA\u640d\u50b7\u3068\u8a00\u3044\u307e\u3059\uff09\u3001\u3053\u306eDNA\u640d\u50b7\u306e\u7a0b\u5ea6\u304c\u5fc3\u4e0d\u5168\u306e\u75c5\u614b\u306e\u7a0b\u5ea6\u3092\u898f\u5b9a\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u3092\u898b\u51fa\u3057\u3066\u3044\u307e\u3057\u305f\uff08Nomura, et al. <em>Nat Commun.<\/em> 2018\uff09\uff08<a href=\"https:\/\/www.genome.rcast.u-tokyo.ac.jp\/3939\">\u30ea\u30f3\u30af<\/a>\uff09\u3002<\/p>\n<p>\u3000\u3055\u3089\u306b\u3001\u5019\u8061\u5fd7\u7814\u7a76\u54e1\u3001\u5927\u5b66\u9662\u751f\u306e\u85e4\u7530\u5bdb\u5948\u3089\u3068\u3001\u30d2\u30c8\u5fc3\u7b4b\u7d30\u80de\u306eDNA\u640d\u50b7\u306e\u7a0b\u5ea6\u3092\u89e3\u6790\u3059\u308b\u624b\u6cd5\u3092\u69cb\u7bc9\u3057\u300158\u4f8b\u306e\u5fc3\u4e0d\u5168\u60a3\u8005\uff08\u62e1\u5f35\u578b\u5fc3\u7b4b\u75c7\u3068\u3044\u3046\u539f\u56e0\u4e0d\u660e\u306e\u5fc3\u7b4b\u969c\u5bb3\u306b\u3088\u308a\u5fc3\u4e0d\u5168\u3068\u306a\u3063\u305f\u60a3\u8005\uff09\u306e\u5fc3\u7b4bDNA\u640d\u50b7\u3092\u53cd\u6620\u3059\u308b\u30de\u30fc\u30ab\u30fc\u3068\u3057\u3066poly(ADP-ribose) \u3068\u03b3-H2A.X\u306e\u514d\u75ab\u67d3\u8272\u89e3\u6790\u3092\u884c\u3044\u307e\u3057\u305f\u3002\u6cbb\u7642\u5fdc\u7b54\u6027\u3084\u4e88\u5f8c\u304c\u60aa\u3044\u60a3\u8005\u306b\u304a\u3044\u3066\u3001\u6cbb\u7642\u524d\u306e\u5fc3\u7b4bDNA\u640d\u50b7\u306e\u7a0b\u5ea6\u304c\u6709\u610f\u306b\u5f37\u3044\u3053\u3068\u304c\u308f\u304b\u308a\u3001\u6cbb\u7642\u524d\u306e\u5fc3\u7b4bDNA\u640d\u50b7\u306e\u7a0b\u5ea6\u306b\u3088\u3063\u3066\u3001\u9ad8\u3044\u7cbe\u5ea6\u3067\uff08\u611f\u5ea6\u30fb\u7279\u7570\u5ea6\u3068\u3082\u306b8\u5272\u7a0b\u5ea6\uff09\u6cbb\u7642\u5fdc\u7b54\u6027\u3092\u4e88\u6e2c\u3067\u304d\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u3002\u672c\u624b\u6cd5\u306f\u3001\u81e8\u5e8a\u73fe\u5834\u306b\u304a\u3044\u3066\u8a3a\u65ad\u76ee\u7684\u3067\u63a1\u53d6\u3059\u308b\u5fc3\u7b4b\u751f\u691c\u7d44\u7e54\u306e\u691c\u4f53\u3092\u7528\u3044\u308b\u65b9\u6cd5\u3067\u3042\u308b\u3053\u3068\u304b\u3089\u3001\u60a3\u8005\u3078\u306e\u8ffd\u52a0\u3068\u306a\u308b\u4fb5\u8972\u304c\u5b58\u5728\u3057\u306a\u3044\u3053\u3068\u3082\u975e\u5e38\u306b\u5927\u304d\u306a\u5229\u70b9\u3067\u3059\u3002\u4ee5\u4e0a\u306e\u6280\u8853\u306f\u5fc3\u4e0d\u5168\u60a3\u8005\u306e\u6cbb\u7642\u306b\u304a\u3044\u3066\u5f85\u671b\u3055\u308c\u3066\u3044\u305f\u300c\u6cbb\u7642\u5fdc\u7b54\u6027\u306e\u4e8b\u524d\u4e88\u6e2c\u300d\u3092\u53ef\u80fd\u306b\u3059\u308b\u624b\u6cd5\u3068\u3057\u3066\u3001\u5fc3\u4e0d\u5168\u81e8\u5e8a\u306b\u304a\u3044\u3066\u300c\u7cbe\u5bc6\u533b\u7642\u300d\u3092\u5b9f\u8df5\u3059\u308b\u4e0a\u3067\u306e\u57fa\u76e4\u7684\u6280\u8853\u3068\u306a\u308b\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.genome.rcast.u-tokyo.ac.jp\/wp-content\/uploads\/2019\/11\/F1.large_-776x1024.jpg\" alt=\"\" class=\"wp-image-4141\" width=\"267\" height=\"352\" srcset=\"https:\/\/www.genome.rcast.u-tokyo.ac.jp\/wp-content\/uploads\/2019\/11\/F1.large_-776x1024.jpg 776w, https:\/\/www.genome.rcast.u-tokyo.ac.jp\/wp-content\/uploads\/2019\/11\/F1.large_-227x300.jpg 227w, https:\/\/www.genome.rcast.u-tokyo.ac.jp\/wp-content\/uploads\/2019\/11\/F1.large_-768x1013.jpg 768w, https:\/\/www.genome.rcast.u-tokyo.ac.jp\/wp-content\/uploads\/2019\/11\/F1.large_.jpg 970w\" sizes=\"auto, (max-width: 267px) 100vw, 267px\" \/><\/figure><\/div>\n\n\n\n<p>\u3000\u672c\u7814\u7a76\u306f\u6771\u4eac\u5927\u5b66\u533b\u5b66\u90e8\u9644\u5c5e\u75c5\u9662 \u5faa\u74b0\u5668\u5185\u79d1\uff08\u5c0f\u5ba4\u4e00\u6210\u6559\u6388\uff09\u3068\u306e\u5171\u540c\u7814\u7a76\u306b\u3088\u308a\u884c\u308f\u308c\u305f\u3082\u306e\u3067\u3001\u79d1\u5b66\u96d1\u8a8cJACC: Basic to Translational Science\u306b\u3066\u672c\u5e749\u670825\u65e5\u306b\u30aa\u30f3\u30e9\u30a4\u30f3\u516c\u958b\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<p>\u96d1\u8a8c\u540d\uff1aJACC: Basic to Translational Science<\/p>\n<p>\u8ad6\u6587\u30bf\u30a4\u30c8\u30eb\uff1a<a href=\"http:\/\/basictranslational.onlinejacc.org\/content\/4\/6\/670\">Quantification of DNA Damage in Heart\u00a0Tissue as a Novel Prediction Tool for Therapeutic Prognosis of Patients With Dilated Cardiomyopathy<\/a><\/p>\n<p>\u8457\u8005\uff1a<span class=\"highwire-citation-author first\" data-delta=\"0\">Toshiyuki Ko<\/span>, <span class=\"highwire-citation-author\" data-delta=\"1\">Kanna Fujita<\/span>, <span class=\"highwire-citation-author\" data-delta=\"2\">Seitaro Nomura<\/span>, <span class=\"highwire-citation-author\" data-delta=\"3\">Yukari Uemura<\/span>, <span class=\"highwire-citation-author\" data-delta=\"4\">Shintaro Yamada<\/span>, <span class=\"highwire-citation-author\" data-delta=\"5\">Takashige Tobita<\/span>, <span class=\"highwire-citation-author\" data-delta=\"6\">Manami Katoh<\/span>, <span class=\"highwire-citation-author\" data-delta=\"7\">Masahiro Satoh<\/span>, <span class=\"highwire-citation-author\" data-delta=\"8\">Masamichi Ito<\/span>, <span class=\"highwire-citation-author\" data-delta=\"9\">Yukako Domoto<\/span>, <span class=\"highwire-citation-author\" data-delta=\"10\">Yumiko Hosoya<\/span>, <span class=\"highwire-citation-author\" data-delta=\"11\">Eisuke Amiya<\/span>, <span class=\"highwire-citation-author\" data-delta=\"12\">Masaru Hatano<\/span>, <span class=\"highwire-citation-author\" data-delta=\"13\">Hiroyuki Morita<\/span>, <span class=\"highwire-citation-author\" data-delta=\"14\">Masashi Fukayama<\/span>, <span class=\"highwire-citation-author\" data-delta=\"15\">Hiroyuki Aburatani<\/span> and <span class=\"highwire-citation-author\" data-delta=\"16\">Issei Komuro<\/span><\/p>\n<div class=\"journal-title\">JACC: Basic to Translational Science<\/div>\n<div class=\"meta-line\"><i class=\"highwire-oa-indicator\"><\/i><span class=\"highwire-cite-metadata-date highwire-cite-metadata\"><a class=\"\" title=\"TOC\" href=\"http:\/\/basictranslational.onlinejacc.org\/content\/4\/6\" data-icon-position=\"\" data-hide-link-title=\"0\">Volume 4, Issue 6, October 2019<\/a><\/span><\/div>\n<div class=\"meta-line\"><span class=\"highwire-cite-metadata-doi highwire-cite-metadata\"><span class=\"label\">DOI:<\/span> 10.1016\/j.jacbts.2019.05.010<\/span><\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u3000\u5fc3\u4e0d\u5168\u306f\u3001\u3055\u307e\u3056\u307e\u306a\u539f\u56e0\u306b\u3088\u308a\u5fc3\u81d3\u306e\u6a5f\u80fd\u304c\u60aa\u304f\u306a\u308a\u3001\u606f\u5207\u308c\u3084\u3080\u304f\u307f\u304c\u751f\u3058\u3001\u304c\u3093\u3068\u4e26\u3093\u3067\u4e16\u754c\u4e2d\u306e\u4eba\u306e\u547d\u3092\u8105\u304b\u3059\u75c5\u6c17\u3067\u3059\u3002\u5fc3\u4e0d\u5168\u306e\u7d4c\u904e\u3084\u6cbb\u7642\u306b\u5bfe\u3059\u308b\u52b9\u679c\u306f\u975e\u5e38\u306b\u591a\u69d8\u3067\u3042\u308a\u3001\u6cbb\u7642\u304c\u594f\u52b9\u3057\u3066\u5fc3\u81d3\u306e\u6a5f\u80fd\u304c\u56de\u5fa9\u3059\u308b\u60a3\u8005\u304c\u3044\u308b\u4e00\u65b9\u3067 &hellip; <a href=\"https:\/\/www.genome.rcast.u-tokyo.ac.jp\/en\/%e5%bf%83%e4%b8%8d%e5%85%a8%e6%82%a3%e8%80%85%e3%81%ae%e6%b2%bb%e7%99%82%e5%bf%9c%e7%ad%94%e6%80%a7%e3%82%84%e4%ba%88%e5%be%8c%e3%82%92%e5%bf%83%e7%ad%8bdna%e6%90%8d%e5%82%b7%e3%81%ae%e7%a8%8b\/\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":54,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[16],"tags":[],"class_list":["post-4140","post","type-post","status-publish","format-standard","hentry","category-news"],"_links":{"self":[{"href":"https:\/\/www.genome.rcast.u-tokyo.ac.jp\/en\/wp-json\/wp\/v2\/posts\/4140","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.genome.rcast.u-tokyo.ac.jp\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.genome.rcast.u-tokyo.ac.jp\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.genome.rcast.u-tokyo.ac.jp\/en\/wp-json\/wp\/v2\/users\/54"}],"replies":[{"embeddable":true,"href":"https:\/\/www.genome.rcast.u-tokyo.ac.jp\/en\/wp-json\/wp\/v2\/comments?post=4140"}],"version-history":[{"count":5,"href":"https:\/\/www.genome.rcast.u-tokyo.ac.jp\/en\/wp-json\/wp\/v2\/posts\/4140\/revisions"}],"predecessor-version":[{"id":4386,"href":"https:\/\/www.genome.rcast.u-tokyo.ac.jp\/en\/wp-json\/wp\/v2\/posts\/4140\/revisions\/4386"}],"wp:attachment":[{"href":"https:\/\/www.genome.rcast.u-tokyo.ac.jp\/en\/wp-json\/wp\/v2\/media?parent=4140"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.genome.rcast.u-tokyo.ac.jp\/en\/wp-json\/wp\/v2\/categories?post=4140"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.genome.rcast.u-tokyo.ac.jp\/en\/wp-json\/wp\/v2\/tags?post=4140"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}