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\u3073\u9769\u65b0\u7684\u304c\u3093\u533b\u7642\u5b9f\u7528\u5316\u7814\u7a76\u4e8b\u696d\u3001\u79d1\u5b66\u7814\u7a76\u88dc\u52a9\u91d1\u306e\u652f\u63f4\u3092\u53d7\u3051\u3066\u884c\u308f\u308c\u307e\u3057\u305f\u3002\u672c\u7814\u7a76\u6210 \u679c\u306f\u7c73\u79d1\u5b66\u8a8c\u300eScience Advances\u300f\u3067 2020\u5e745\u67087\u65e5\u306b\u516c\u958b\u3055\u308c\u307e\u3059\u3002<\/p>\r\n<\/div>\r\n<\/div>\r\n<\/div>\r\n<\/div>\r\n<\/div>\r\n<\/div>\r\n\r\n\r\n\r\n<div class=\"page\" title=\"Page 2\">\r\n<div class=\"layoutArea\">\r\n<div class=\"column\">\r\n<p><strong>\u767a\u8868\u5185\u5bb9<\/strong><\/p>\r\n<p>\u672c\u7814\u7a76\u3067\u306f\u3001243\u540d\u306e\u65e5\u672c\u4eba\u80c3\u304c\u3093\u75c7\u4f8b\u304a\u3088\u3073TCGA (https:\/\/www.cancer.gov\/tcga)\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u306b\u3042\u308b 288 \u540d\u306e\u80c3\u304c\u3093\u75c7\u4f8b\u306b\u5bfe\u3059\u308b\u5168\u30a8\u30af\u30bd\u30fc\u30e0\u30b7\u30fc\u30b1\u30f3\u30b9(\u6ce86)\u30c7\u30fc\u30bf\u3092\u7d71\u5408\u3057\u3001\u30a2\u30b8\u30a2\u4eba 319 \u75c7\u4f8b\u3068\u975e\u30a2\u30b8\u30a2\u4eba 212 \u75c7\u4f8b\u3001\u5408\u8a08 531 \u75c7\u4f8b\u306e\u4eba\u7a2e\u6a2a\u65ad\u7684\u80c3\u304c\u3093\u30b2\u30ce\u30e0\u89e3\u6790 \u3092\u884c\u3044\u307e\u3057\u305f\u3002<\/p>\r\n<p>\u5909\u7570\u30b7\u30b0\u30cd\u30c1\u30e3\u3068\u547c\u3070\u308c\u308b\u4f53\u7d30\u80de\u30b2\u30ce\u30e0\u5909\u7570\u306e\u30d1\u30bf\u30fc\u30f3\u306b\u3088\u3063\u3066 531 \u4f8b\u3092\u5206\u985e\u3057\u305f\u3068\u3053\u308d\u3001 \u30a2\u30eb\u30b3\u30fc\u30eb\u6442\u53d6\u306b\u3088\u3063\u3066\u8d77\u3053\u308b\u3068\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u5909\u7570\u30b7\u30b0\u30cd\u30c1\u30e3\u300c\u30b7\u30b0\u30cd\u30c1\u30e3 16\u300d(\u6ce87)\u304c\u512a\u4f4d\u306b\u8a8d\u3081\u3089\u308c\u308b\u30af\u30e9\u30b9\u30bf\u30fc\u304c\u5b58\u5728\u3059\u308b\u3053\u3068\u3092\u898b\u3044\u3060\u3057\u307e\u3057\u305f(\u56f3 1)\u3002\u307e\u305f\u3053\u306e\u30af\u30e9\u30b9\u30bf\u30fc\u4e2d\u306e\u75c7\u4f8b\u306e\u591a\u304f\u304c\u30a2\u30b8\u30a2\u4eba\u3067\u3042\u308a\u3001\u3055\u3089\u306b ALDH2(\u30a2\u30eb\u30b3\u30fc\u30eb\u5206\u89e3\u9175\u7d20)\u907a\u4f1d\u5b50\u591a\u578b\u306e\u3046\u3061\u30a2\u30eb\u30b3\u30fc\u30eb\u3092\u5206\u89e3\u3067\u304d\u306a\u3044\u30bf\u30a4\u30d7\u306e\u30a2\u30ec\u30eb (rs671-AA or AG)\u3092\u4fdd\u6709\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3057\u305f\u3002<\/p>\r\n<p>\u751f\u6d3b\u7fd2\u6163\u3068\u80c3\u304c\u3093\u30b2\u30ce\u30e0\u3068\u306e\u95a2\u9023\u306b\u3064\u3044\u3066\u8a73\u7d30\u306a\u89e3\u6790\u3092\u884c\u3046\u305f\u3081\u3001\u65e5\u672c\u4eba\u80c3\u304c\u3093\u75c7\u4f8b\u306b\u9650 \u3063\u305f\u89e3\u6790\u3092\u884c\u3063\u305f\u3068\u3053\u308d\u3001\u30b7\u30b0\u30cd\u30c1\u30e3 16 \u304c\u512a\u4f4d\u306a\u30af\u30e9\u30b9\u30bf\u30fc\u306f\u80c3\u304c\u3093\u75c7\u4f8b\u5168\u4f53\u306e 6.6% (16\/243)\u3092\u5360\u3081\u3066\u3044\u307e\u3057\u305f\u3002\u305d\u306e\u591a\u304f\u306f\u4e0d\u6d3b\u6027\u578b ALDH2 \u30a2\u30ec\u30eb\u3092\u6301\u3061\u3001\u304b\u3064\u98f2\u9152\u304a\u3088\u3073\u55ab\u7159 \u306e\u7fd2\u6163\u304c\u3042\u308b\u75c7\u4f8b\u3067\u3057\u305f\u3002\u4e0d\u6d3b\u6027\u578bALDH2 \u30a2\u30ec\u30eb (rs671-AA or AG)\u306f\u65e5\u672c\u30fb\u97d3\u56fd\u3084\u4e2d\u56fd\u6771\u90e8\u306a\u3069\u6771\u30a2\u30b8\u30a2\u306b\u7279\u6709\u306b\u898b\u3089\u308c\u308b\u591a\u578b\u3067\u3001\u3053\u306e\u907a\u4f1d\u5b50\u591a\u578b\u3068\u98f2\u9152\u7fd2\u6163\u3068\u306e\u639b\u3051\u5408\u308f\u305b\u3067\u30b7\u30b0\u30cd\u30c1\u30e3 16 \u304c\u512a\u4f4d\u306a\u304c\u3093\u304c\u767a\u75c7\u3059\u308b\u3053\u3068\u306f\u6771\u30a2\u30b8\u30a2\u4eba\u306b\u7279\u6709\u306e\u73fe\u8c61\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002\u8208\u5473\u6df1\u3044\u3053\u3068\u306b\u4e0d\u6d3b\u6027\u578b ALDH2 \u30a2\u30ec\u30eb\u3092\u6301\u3064\u75c7\u4f8b\u306b\u304a\u3044\u3066\u3001\u98f2\u9152\u7fd2\u6163\u306e\u307f\u3042\u308b\u3044\u306f\u55ab\u7159\u7fd2\u6163\u306e\u307f\u306e\u75c7 \u4f8b\u306b\u6bd4\u8f03\u3057\u3066\u3001\u98f2\u9152\u30fb\u55ab\u7159\u4e21\u65b9\u306e\u7fd2\u6163\u3092\u6301\u3064\u75c7\u4f8b\u3067\u76f8\u4e57\u7684\u306b\u30b7\u30b0\u30cd\u30c1\u30e3 16 \u306e\u30b2\u30ce\u30e0\u5909\u7570\u304c\u84c4\u7a4d\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3057\u305f(\u56f3 2)\u3002\u3053\u306e\u3044\u308f\u3086\u308b\u30a2\u30eb\u30b3\u30fc\u30eb\u30fb\u55ab\u7159\u95a2\u9023\u80c3\u304c\u3093\u306f\u3001\u5168\u4f53\u7684 \u306b\u4f53\u7d30\u80de\u5909\u7570\u306e\u6570\u304c\u5c11\u306a\u304f B \u7d30\u80de\u306e\u6d78\u6f64\u304c\u591a\u3044\u306a\u3069\u306e\u751f\u7269\u5b66\u7684\u7279\u6027\u3092\u6301\u3064\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057 \u305f\u3002\u65e5\u672c\u4eba\u306b\u304a\u3044\u3066\u98f2\u9152\u304c\u80c3\u304c\u3093\u306e\u30ea\u30b9\u30af\u3092\u3042\u3052\u308b\u3053\u3068\u306f\u75ab\u5b66\u7684\u306b\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u55ab\u7159\u7fd2\u6163\u3068\u306e\u639b\u3051\u5408\u308f\u305b\u306b\u3088\u3063\u3066\u30b7\u30b0\u30cd\u30c1\u30e3 16 \u30d1\u30bf\u30fc\u30f3\u306e\u30b2\u30ce\u30e0\u5909\u7570\u5bc6\u5ea6\u304c\u76f8\u4e57\u7684\u306b\u4e0a\u6607\u3059\u308b\u3053\u3068\u306f\u3001\u4eca\u56de\u306e\u7814\u7a76\u306b\u3088\u3063\u3066\u306f\u3058\u3081\u3066\u5206\u304b\u3063\u305f\u3053\u3068\u3067\u3059\u3002<\/p>\r\n<p>\u8fd1\u5e74\u3001\u81e8\u5e8a\u7684\u306b\u554f\u984c\u3068\u306a\u308b\u3088\u3046\u306a\u4e2d\u7a0b\u5ea6\u4ee5\u4e0a\u306e\u304c\u3093\u767a\u75c7\u30ea\u30b9\u30af\u3092\u793a\u3059\u907a\u4f1d\u7684\u7d20\u56e0\u306e\u63a2\u7d22\u306b\u30b2\u30ce\u30e0\u30b7\u30fc\u30b1\u30f3\u30b9\u306b\u3088\u308b\u30ec\u30a2\u30d0\u30ea\u30a2\u30f3\u30c8\u306e\u63a2\u7d22\u304c\u7528\u3044\u3089\u308c\u3001\u6b27\u7c73\u306b\u304a\u3051\u308b\u80c3\u304c\u3093\u306b\u3064\u3044\u3066\u306f PALB2, BRCA1\/2, RAD51\u7b49\u306e\u4e8c\u91cd\u9396\u5207\u65ad\u306e\u76f8\u540c\u7d44\u307f\u63db\u3048\u4fee\u5fa9\u306b\u95a2\u308f\u308b\u907a\u4f1d\u5b50\u306e\u75c5\u7684\u80da\u7d30\u80de\u30d0 \u30ea\u30a2\u30f3\u30c8\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002243 \u306e\u65e5\u672c\u4eba\u80c3\u304c\u3093\u75c7\u4f8b\u306b\u3064\u3044\u3066\u3001\u975e\u816b\u760d\u90e8\u306e\u5168\u30a8\u30af\u30bd\u30fc\u30e0\u914d \u5217\u304b\u3089\u69d8\u3005\u306a\u4eba\u7a2e\u3067\u983b\u5ea6\u304c1%\u672a\u6e80\u3067\u304b\u3064\u75c5\u7684\u610f\u7fa9\u304c\u4e88\u6e2c\u3055\u308c\u308b\u30ec\u30a2\u30d0\u30ea\u30a2\u30f3\u30c8\u306e\u89e3\u6790\u3092\u884c\u3063\u305f\u3068\u3053\u308d\u3001624 \u7a2e\u985e\u306e\u304c\u3093\u95a2\u9023\u907a\u4f1d\u5b50\u306e\u306a\u304b\u3067 E-\u30ab\u30c9\u3078\u30ea\u30f3\u907a\u4f1d\u5b50\u304c\u6700\u3082\u30d0\u30ea\u30a2\u30f3\u30c8\u5bc6\u5ea6\u304c\u9ad8\u3044\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\u3002E-\u30ab\u30c9\u3078\u30ea\u30f3\u306f\u7d30\u80de\u9593\u63a5\u7740\u5206\u5b50\u3068\u3057\u3066\u6709\u540d\u306a\u30bf\u30f3\u30d1\u30af\u3067\u3042\u308a\u3001\u907a\u4f1d\u6027\u3073\u307e\u3093\u578b\u80c3\u304c\u3093\u306e\u539f\u56e0\u907a\u4f1d\u5b50\u3068\u3057\u3066\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002243 \u306e\u80c3\u304c\u3093\u75c7\u4f8b\u306e\u3046\u3061 18 \u75c7\u4f8b(7.4%)\u3067 E-\u30ab\u30c9\u3078\u30ea\u30f3\u907a\u4f1d\u5b50\u306b\u30a2\u30df\u30ce\u9178\u7f6e\u63db\u3092\u4f34\u3046\u30d0\u30ea\u30a2\u30f3\u30c8\u304c\u307f\u3089\u308c\u307e\u3057\u305f(\u56f3 3)\u3002 \u91cd\u8981\u306a\u6240\u898b\u3068\u3057\u3066\u3001\u3053\u308c\u3089\u306e\u30d0\u30ea\u30a2\u30f3\u30c8\u3092\u6301\u3064 18 \u75c7\u4f8b\u306e\u3046\u3061\u5927\u90e8\u5206\u306e 14 \u75c7\u4f8b\u304c\u3073\u307e\u3093\u578b\u80c3\u304c\u3093(\u4f4e\u5206\u5316\u578b\u80c3\u304c\u3093)\u3067\u3042\u308a\u3001\u89e3\u6790\u3057\u305f 243 \u75c7\u4f8b\u4e2d\u306e\u3073\u307e\u3093\u578b\u80c3\u304c\u3093\u306e\u5272\u5408(43.2%)\u3068\u6bd4\u8f03\u3057\u3066\u5927\u304d\u304f\u504f\u3063\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u7d50\u679c\u306f\u975e\u30a2\u30b8\u30a2\u4eba\u3067\u898b\u3064\u304b\u3063\u305f\u30d0\u30ea\u30a2\u30f3\u30c8\u3068\u5bfe\u7167\u7684\u3067\u3042\u308a\u3001\u3073\u307e\u3093\u578b\u80c3\u304c\u3093\u304c E-\u30ab\u30c9\u3078\u30ea\u30f3\u306e\u6a5f\u80fd\u55aa\u5931\u306b\u3088\u3063\u3066\u8d77\u3053\u308b\u3053\u3068\u3092\u8003\u3048\u308b\u3068\u3001\u3053\u308c\u3089\u306e\u30ec\u30a2\u30d0\u30ea\u30a2\u30f3\u30c8\u304c\u75c5\u7684\u80da\u7d30\u80de\u30d0\u30ea\u30a2\u30f3\u30c8\u3068\u3057\u3066\u3073\u307e\u3093\u578b\u80c3\u304c\u3093\u306e\u767a\u75c7\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u5f37\u304f\u793a\u3059\u7d50\u679c\u3067\u3059\u3002E-\u30ab\u30c9\u3078\u30ea\u30f3\u907a\u4f1d\u5b50\u306e\u75c5\u7684\u80da\u7d30\u80de\u30d0\u30ea\u30a2\u30f3\u30c8\u306f\u65e5\u672c\u4eba\u306e\u3073\u307e\u3093\u578b\u80c3\u304c\u3093\u75c7\u4f8b\u4e2d 13.3% (14\/105)\u306b\u8a8d\u3081\u3089\u308c\u307e\u3057\u305f\u3002<\/p>\r\n<\/div>\r\n<\/div>\r\n<\/div>\r\n<div class=\"page\" title=\"Page 3\">\r\n<div class=\"layoutArea\">\r\n<div class=\"column\">\r\n<p>\u4eca\u56de\u898b\u3064\u304b\u3063\u305f E-\u30ab\u30c9\u3078\u30ea\u30f3\u907a\u4f1d\u5b50\u306e\u75c5\u7684\u80da\u7d30\u80de\u30d0\u30ea\u30a2\u30f3\u30c8\u306f 5 \u30ab\u6240\u306b\u96c6\u4e2d\u3057\u3066\u304a\u308a\u3001\u65e5\u672c\u4eba\u96c6\u56e3\u4e2d\u3067\u306f 1%\u4ee5\u4e0b\u3067\u306f\u3042\u308b\u3082\u306e\u306e\u4e00\u5b9a\u306e\u983b\u5ea6\u3067\u5b58\u5728\u3057\u3001\u975e\u30a2\u30b8\u30a2\u4eba\u75c7\u4f8b\u306b\u306f\u5168\u304f\u8a8d\u3081\u3089\u308c\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u305d\u306e\u4e00\u65b9\u3067\u65e5\u672c\u4eba\u3068\u97d3\u56fd\u4eba\u306b\u306f\u5171\u901a\u3057\u3066\u307f\u3089\u308c\u308b\u3053\u3068\u304b\u3089\u3001\u5c11\u306a\u304f\u3068\u3082\u6771\u30a2\u30b8\u30a2\u4e00\u5e2f\u306b\u5e83\u304f\u5206\u5e03\u3059\u308b\u30a2\u30ec\u30eb\u3067\u3042\u308a\u3001\u3053\u306e\u4e00\u5e2f\u304c\u80c3\u304c\u3093\u306e\u9ad8\u983b\u5ea6\u5730\u57df\u306b\u306a\u3063\u3066\u3044\u308b\u539f\u56e0\u306e\u4e00\u3064\u3067\u3042\u308b\u53ef\u80fd\u6027\u3082\u8003\u3048\u3089\u308c\u307e\u3057\u305f\u3002\u898b\u3064\u304b\u3063\u305f\u30ec\u30a2\u30d0\u30ea\u30a2\u30f3\u30c8\u306e\u306a\u304b\u306b\u306f V832M \u3084 G62V 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\u660e\u78ba\u3067\u306f\u306a\u304f\u81e8\u5e8a\u7684\u306b\u5b64\u767a\u4f8b\u3060\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u305f\u3073\u307e\u3093\u578b\u80c3\u304c\u3093\u75c7\u4f8b\u306e\u306a\u304b\u306b\u3001E-\u30ab\u30c9\u3078\u30ea \u30f3\u907a\u4f1d\u5b50\u306e\u75c5\u7684\u80da\u7d30\u80de\u30d0\u30ea\u30a2\u30f3\u30c8\u3092\u6709\u3059\u308b\u75c7\u4f8b\u304c 1 \u5272\u4ee5\u4e0a\u306e\u9ad8\u3044\u983b\u5ea6\u3067\u542b\u307e\u308c\u3066\u3044\u308b\u3053\u3068\u306f\u3001 \u91cd\u8981\u306a\u77e5\u898b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\r\n<p>\u80c3\u304c\u3093\u30b2\u30ce\u30e0\u7814\u7a76\u306b\u3088\u3063\u3066\u660e\u3089\u304b\u306b\u3055\u308c\u305f\u3001\u907a\u4f1d\u7684\u7d20\u56e0\u3084\u74b0\u5883\u56e0\u5b50\u3068\u306e\u76f8\u4e92\u4f5c\u7528\u306b\u3088\u308b\u65e5\u672c\u4eba\u306e\u80c3\u304c\u3093\u30ea\u30b9\u30af\u306e\u89e3\u660e\u306f\u3001\u81e8\u5e8a\u7684\u30fb\u793e\u4f1a\u7684\u306b\u91cd\u8981\u306a\u610f\u7fa9\u3092\u6301\u3064\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002\u4eca\u56de\u306e\u7d50\u679c\u3067\u306f\u3073\u307e\u3093\u578b\u80c3\u304c\u3093\u75c7\u4f8b\u306e\u7d04 5 \u5206\u306e 1 (22\/105, 21.0%)\u304c\u3001\u4e0d\u6d3b\u6027\u578b ALDH2 \u3068\u30a2\u30eb\u30b3\u30fc\u30eb\u6442\u53d6\u30fb\u55ab\u7159\u7fd2\u6163\u306e\u7d44\u307f\u5408\u308f\u305b\u3001\u307e\u305f\u306f E-\u30ab\u30c9\u3078\u30ea\u30f3\u306e\u75c5\u7684\u80da\u7d30\u80de\u30d0\u30ea\u30a2\u30f3\u30c8\u306b\u95a2\u9023\u3057\u3066\u3044\u307e\u3057\u305f\u3002\u80c3\u304c\u3093\u306e\u30cf\u30a4\u30ea\u30b9\u30af\u7fa4\u3092\u907a\u4f1d\u7684\u7d20\u56e0\u306b\u3088\u3063\u3066\u7d5e\u308a\u8fbc\u307f\u3001\u98f2\u9152\u30fb\u55ab\u7159\u3068\u3044\u3063\u305f\u751f\u6d3b\u7fd2\u6163\u3092\u6539\u5584\u3059\u308b\u3053\u3068\u306b\u3088\u308b\u4e88\u9632\u3084\u3001\u8840\u7e01\u8005\u3092\u542b\u3081\u305f\u7dbf\u5bc6\u306a\u5185\u8996\u93e1\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u7b49\u306b\u3088\u308b\u65e9\u671f\u767a\u898b\u306a\u3069\u306e\u52b9\u679c\u7684\u4ecb\u5165\u3092\u884c\u3046\u305f\u3081\u306e\u91cd\u8981\u306a\u77e5\u898b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\r\n<\/div>\r\n<\/div>\r\n<\/div>\r\n\r\n\r\n\r\n<div class=\"page\" title=\"Page 3\">\r\n<div class=\"layoutArea\">\r\n<div class=\"column\">\r\n<p><strong>\u767a\u8868\u96d1\u8a8c<\/strong><\/p>\r\n<p>\u96d1\u8a8c\u540d:\u300cScience Advances\u300d(\u30aa\u30f3\u30e9\u30a4\u30f3: 5 \u6708 7 \u65e5)<br>\u8ad6\u6587\u30bf\u30a4\u30c8\u30eb:Defined Lifestyle and Germline Factors Predispose Asian Populations to Gastric Cancer.<\/p>\r\n<\/div>\r\n<\/div>\r\n<\/div>\r\n\r\n\r\n\r\n<div class=\"page\" title=\"Page 4\">\r\n<div class=\"layoutArea\">\r\n<div class=\"column\">\r\n<p>\u8457\u8005:Akihiro Suzuki, Hiroto Katoh, Daisuke Komura, Miwako Kakiuchi, Amane Tagashira, Shogo Yamamoto, Kenji Tatsuno, Hiroki Ueda, Genta Nagae, Shiro Fukuda, Takayoshi Umeda, Yasushi Totoki, Hiroyuki Abe, Tetsuo Ushiku, Tetsuya Matsuura, Eiji Sakai, Takashi Ohshima, Sachiyo Nomura, Yasuyuki, Seto, Tatsuhiro Shibata, Yasushi Rino, Atsushi Nakajima, Masashi Fukayama, Shumpei Ishikawa*, Hiroyuki Aburatani* (*\u306f\u5171\u540c\u8cac\u4efb\u8457\u8005)<\/p>\r\n<p>DOI \u756a\u53f7:10.1126\/sciadv.aav9778<\/p>\r\n<p>\u30a2\u30d6\u30b9\u30c8\u30e9\u30af\u30c8 URL: <a href=\"https:\/\/advances.sciencemag.org\/content\/6\/19\/eaav9778\">https:\/\/advances.sciencemag.org\/content\/6\/19\/eaav9778<\/a><\/p>\r\n<\/div>\r\n<\/div>\r\n<\/div>\r\n\r\n\r\n\r\n<div class=\"page\" title=\"Page 4\">\r\n<div class=\"layoutArea\">\r\n<div class=\"column\">\r\n<p><strong>\u554f\u3044\u5408\u308f\u305b\u5148<\/strong><\/p>\r\n<p>\u3010\u7814\u7a76\u306b\u95a2\u3059\u308b\u554f\u3044\u5408\u308f\u305b\u5148\u3011<br>\u6771\u4eac\u5927\u5b66 \u5927\u5b66\u9662\u533b\u5b66\u7cfb\u7814\u7a76\u79d1 \u885b\u751f\u5b66\u5206\u91ce \u6559\u6388 \u77f3\u5ddd \u4fca\u5e73 (\u3044\u3057\u304b\u308f \u3057\u3085\u3093\u307a\u3044)<\/p>\r\n<p>E-mail: ishum-prm[at]m.u-tokyo.ac.jp<br>\u6771\u4eac\u5927\u5b66 \u5148\u7aef\u79d1\u5b66\u6280\u8853\u7814\u7a76\u30bb\u30f3\u30bf\u30fc \u30b2\u30ce\u30e0\u30b5\u30a4\u30a8\u30f3\u30b9\u90e8\u9580<\/p>\r\n<p>\u6559\u6388 \u6cb9\u8c37 \u6d69\u5e78(\u3042\u3076\u3089\u305f\u306b \u3072\u308d\u3086\u304d) E-mail: haburata-tky[at]umin.ac.jp<\/p>\r\n<p>\u3010\u4e8b\u696d\u306b\u95a2\u3059\u308b\u554f\u3044\u5408\u308f\u305b\u5148\u3011 \u56fd\u7acb\u7814\u7a76\u958b\u767a\u6cd5\u4eba \u65e5\u672c\u533b\u7642\u7814\u7a76\u958b\u767a\u6a5f\u69cb (AMED) \u5275\u85ac\u4e8b\u696d\u90e8 \u533b\u85ac\u54c1\u7814\u7a76\u958b\u767a\u8ab2<\/p>\r\n<p>E-mail: cancer[at]amed.go.jp<\/p>\r\n<\/div>\r\n<p>\u203b[at]\u306f@\uff08\u30a2\u30c3\u30c8\u30de\u30fc\u30af\uff09<\/p>\r\n<\/div>\r\n<\/div>\r\n\r\n\r\n\r\n<div class=\"page\" title=\"Page 4\">\r\n<div class=\"layoutArea\">\r\n<div class=\"column\">\r\n<p><strong>\u7528\u8a9e\u89e3\u8aac<\/strong><br \/>(\u6ce81) \u591a\u578b:\u57fa\u672c\u7684\u306b\u4f53\u3092\u69cb\u6210\u3059\u308b\u3059\u3079\u3066\u306e\u7d30\u80de\u304c\u6301\u3064\u30b2\u30ce\u30e0\u914d\u5217\u306e\u500b\u4eba\u5dee\u3067\u3042\u308a\u89aa\u304b\u3089\u306b\u53d7\u3051\u7d99\u304c\u308c\u308b\u3002\u7279\u306b\u4eba\u53e3\u96c6\u56e3\u3067\u983b\u5ea6\u304c\u6bd4\u8f03\u7684\u9ad8\u3044\u3082\u306e(1%\u4ee5\u4e0a)\u306e\u3082\u306e\u306f\u591a\u578b\u3068\u547c\u3070\u308c\u308b\u3002<\/p>\r\n<p>(\u6ce82) \u80da\u7d30\u80de\u30d0\u30ea\u30a2\u30f3\u30c8:\u591a\u578b\u3068\u540c\u3058\u304f\u89aa\u304b\u3089\u5b50\u306b\u53d7\u3051\u7d99\u304c\u308c\u308b\u30b2\u30ce\u30e0\u914d\u5217\u306e\u500b\u4eba\u5dee\u3067\u3042\u308a\u3001\u591a\u578b\u3092\u542b\u3081\u4eba\u53e3\u96c6\u56e3\u3067\u983b\u5ea6\u306e\u9ad8\u3044\u3082\u306e\u304b\u3089\u4f4e\u3044\u3082\u306e\u5168\u4f53\u3092\u3055\u3059\u3002\u7279\u306b 1%\u672a\u6e80\u306e\u3082\u306e\u306f \u30ec\u30a2\u30d0\u30ea\u30a2\u30f3\u30c8\u3068\u547c\u3070\u308c\u308b\u3053\u3068\u304c\u3042\u308b\u3002\u591a\u304f\u306f\u30d2\u30c8\u5f62\u8cea\u3084\u75be\u60a3\u306b\u5f71\u97ff\u3092\u53ca\u307c\u3055\u306a\u3044\u304c\u3001 \u75be\u60a3\u30ea\u30b9\u30af\u4e0a\u6607\u306a\u3069\u75c5\u7684\u610f\u7fa9\u304c\u3042\u308b\u3082\u306e\u306f\u75c5\u7684\u80da\u7d30\u80de\u30d0\u30ea\u30a2\u30f3\u30c8\u3068\u547c\u3070\u308c\u308b\u3002<\/p>\r\n<p>(\u6ce83) \u4f53\u7d30\u80de\u30b2\u30ce\u30e0\u5909\u7570:\u3053\u3053\u3067\u306f\u304c\u3093\u7d30\u80de\u306e\u30b2\u30ce\u30e0\u306b\u306e\u307f\u5b58\u5728\u3059\u308b\u5909\u7570\u3092\u6307\u3057\u3001\u901a\u5e38\u89aa\u304b \u3089\u5b50\u306b\u907a\u4f1d\u3059\u308b\u3053\u3068\u306f\u306a\u3044\u3002<\/p>\r\n<p>(\u6ce84) \u5909\u7570\u30b7\u30b0\u30cd\u30c1\u30e3(MutationSignature): \u304c\u3093\u306e1\u75c7\u4f8b\u4e2d\u306b\u304a\u3051\u308b\u591a\u304f\u306e\u4f53\u7d30\u80de\u30b2\u30ce\u30e0 \u5909\u7570\u3092\u96c6\u8a08\u3057\u305f\u3068\u304d\u306b\u8a8d\u3081\u3089\u308c\u308b\u5909\u7570\u90e8\u304a\u3088\u3073\u5468\u8fba\u90e8\u306e\u5869\u57fa\u914d\u5217\u306e\u30d1\u30bf\u30fc\u30f3\u3092\u8a00\u3046\u3002\u304c\u3093\u306b\u304a\u3051\u308b\u591a\u69d8\u306a\u5916\u7684\u30fb\u5185\u7684\u56e0\u5b50(\u52a0\u9f62, \u7d2b\u5916\u7dda, \u55ab\u7159\u306a\u3069)\u306b\u5bfe\u5fdc\u3057\u3066\u56fa\u6709\u306e\u5909\u7570 \u30b7\u30b0\u30cd\u30c1\u30e3\u304c\u898b\u3089\u308c\u3001\u4f53\u7d30\u80de\u30b2\u30ce\u30e0\u5909\u7570\u304b\u3089\u5909\u7570\u30b7\u30b0\u30cd\u30c1\u30e3\u3092\u89e3\u6790\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u764c\u306e\u5185\u7684\u30fb\u5916\u7684\u8981\u56e0\u3092\u985e\u63a8\u3059\u308b\u3053\u3068\u304c\u51fa\u6765\u308b\u3002<\/p>\r\n<p>\u3010\u53c2\u8003 URL:<a href=\"https:\/\/cancer.sanger.ac.uk\/cosmic\/signatures_v2\">https:\/\/cancer.sanger.ac.uk\/cosmic\/signatures_v2<\/a>\u3011<\/p>\r\n<\/div>\r\n<\/div>\r\n<\/div>\r\n<div class=\"page\" title=\"Page 5\">\r\n<div class=\"layoutArea\">\r\n<div class=\"column\">\r\n<p>(\u6ce85) \u3073\u307e\u3093\u578b\u80c3\u304c\u3093:\u80c3\u304c\u3093\u306e\u306a\u304b\u306e\u4e3b\u8981\u306a\u30b5\u30d6\u30bf\u30a4\u30d7\u306e\u4e00\u3064\u3002\u4f4e\u5206\u5316\u578b\u80c3\u304c\u3093\u3084\u30b9\u30ad\u30eb \u30b9\u80c3\u304c\u3093\u3068\u547c\u3070\u308c\u308b\u3053\u3068\u3082\u3042\u308a\u3001\u6709\u52b9\u306a\u6cbb\u7642\u6cd5\u304c\u306a\u3044\u96e3\u6cbb\u6027\u306e\u80c3\u304c\u3093\u3067\u3042\u308b\u3002E-\u30ab\u30c9\u30d8\u30ea\u30f3\u907a\u4f1d\u5b50\u306e\u5909\u7570\u306b\u3088\u308a\u907a\u4f1d\u6027\u3073\u307e\u3093\u578b\u80c3\u304c\u3093\u304c\u8d77\u3053\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u308b\u3002<\/p>\r\n<p>(\u6ce86) \u30a8\u30af\u30bd\u30fc\u30e0\u30b7\u30fc\u30b1\u30f3\u30b9:\u30d2\u30c8\u30b2\u30ce\u30e0\u306b\u304a\u3051\u308b\u907a\u4f1d\u5b50\u9818\u57df\u306e\u3046\u3061\u3001\u4e3b\u306b\u6210\u719f\u3057\u305fRNA\u3084 \u30bf\u30f3\u30d1\u30af\u306b\u8ee2\u5199\u30fb\u7ffb\u8a33\u3055\u308c\u308b\u30a8\u30af\u30bd\u30f3\u90e8\u5206\u306e\u307f\u3092\u89e3\u8aad\u3059\u308b\u624b\u6cd5\u3092\u30a8\u30af\u30bd\u30fc\u30e0\u30b7\u30fc\u30b1\u30f3 \u30b9\u3068\u3044\u3046\u3002\u30d2\u30c8\u30b2\u30ce\u30e0\u306e\u306a\u304b\u3067\u6a5f\u80fd\u7684\u306b\u91cd\u8981\u306a\u90e8\u5206\u3092\u52b9\u7387\u3088\u304f\u89e3\u8aad\u3059\u308b\u624b\u6cd5\u3067\u3042\u308b\u3002<\/p>\r\n<p>(\u6ce87) \u30b7\u30b0\u30cd\u30c1\u30e316:\u3053\u308c\u307e\u3067\u6570\u5341\u7a2e\u985e\u77e5\u3089\u308c\u308b\u5909\u7570\u30b7\u30b0\u30cd\u30c1\u30e3\u306e\u3046\u3061\u3001\u30a2\u30eb\u30b3\u30fc\u30eb\u6442\u53d6\u306b \u3088\u3063\u3066\u8d77\u3053\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u308b\u907a\u4f1d\u5b50\u5909\u7570\u30d1\u30bf\u30fc\u30f3\u3002\u98df\u9053\u304c\u3093\u3001\u809d\u81d3\u304c\u3093\u306a\u3069\u30a2\u30eb\u30b3 \u30fc\u30eb\u306b\u95a2\u9023\u3059\u308b\u304c\u3093\u3067\u89b3\u6e2c\u3055\u308c\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u308b\u3002<\/p>\r\n<p>\u00a0<\/p>\r\n<\/div>\r\n<\/div>\r\n<\/div>\r\n\r\n\r\n\r\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"713\" src=\"https:\/\/www.genome.rcast.u-tokyo.ac.jp\/wp-content\/uploads\/2020\/05\/3181b299b887ccc79de9718990109235-1024x713.png\" alt=\"\" class=\"wp-image-4201\" srcset=\"https:\/\/www.genome.rcast.u-tokyo.ac.jp\/wp-content\/uploads\/2020\/05\/3181b299b887ccc79de9718990109235-1024x713.png 1024w, https:\/\/www.genome.rcast.u-tokyo.ac.jp\/wp-content\/uploads\/2020\/05\/3181b299b887ccc79de9718990109235-300x209.png 300w, https:\/\/www.genome.rcast.u-tokyo.ac.jp\/wp-content\/uploads\/2020\/05\/3181b299b887ccc79de9718990109235-768x535.png 768w, https:\/\/www.genome.rcast.u-tokyo.ac.jp\/wp-content\/uploads\/2020\/05\/3181b299b887ccc79de9718990109235-1536x1069.png 1536w, https:\/\/www.genome.rcast.u-tokyo.ac.jp\/wp-content\/uploads\/2020\/05\/3181b299b887ccc79de9718990109235.png 1862w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\r\n\r\n\r\n\r\n<div class=\"page\" title=\"Page 5\">\r\n<div class=\"layoutArea\">\r\n<div class=\"column\">\r\n<p><strong>\u6dfb\u4ed8\u8cc7\u6599<\/strong><\/p>\r\n<\/div>\r\n<\/div>\r\n<img>\r\n<div class=\"layoutArea\">\r\n<div class=\"column\">\r\n<p>\u56f3 1:531 \u75c7\u4f8b\u306e\u4eba\u7a2e\u6a2a\u65ad\u7684\u80c3\u304c\u3093\u30b2\u30ce\u30e0\u89e3\u6790\u306e\u7d50\u679c\u3002\u30a2\u30eb\u30b3\u30fc\u30eb\u6442\u53d6\u306b\u3088\u3063\u3066\u8d77\u3053\u308b\u3053\u3068\u304c \u5831\u544a\u3055\u308c\u3066\u3044\u308b\u300c\u30b7\u30b0\u30cd\u30c1\u30e3 16\u300d\u306e\u30b2\u30ce\u30e0\u5909\u7570\u30d1\u30bf\u30fc\u30f3\u304c\u512a\u4f4d\u306a\u4e00\u7fa4\u304c\u307f\u3089\u308c(\u77e2\u5370)\u3001\u305d\u308c \u3089\u306e\u75c7\u4f8b\u306e\u5927\u90e8\u5206\u304c\u30a2\u30b8\u30a2\u4eba\u3067\u4e0d\u6d3b\u6027\u578b ALDH2 \u30a2\u30ec\u30eb\u3092\u3082\u3064\u3053\u3068\u304c\u5206\u304b\u308b\u3002<\/p>\r\n<\/div>\r\n<\/div>\r\n<\/div>\r\n<div class=\"page\" title=\"Page 6\"><a href=\"https:\/\/www.genome.rcast.u-tokyo.ac.jp\/wp-content\/uploads\/2020\/05\/Figure2.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-4204\" src=\"https:\/\/www.genome.rcast.u-tokyo.ac.jp\/wp-content\/uploads\/2020\/05\/Figure2.png\" alt=\"\" width=\"1236\" height=\"867\" srcset=\"https:\/\/www.genome.rcast.u-tokyo.ac.jp\/wp-content\/uploads\/2020\/05\/Figure2.png 1236w, https:\/\/www.genome.rcast.u-tokyo.ac.jp\/wp-content\/uploads\/2020\/05\/Figure2-300x210.png 300w, https:\/\/www.genome.rcast.u-tokyo.ac.jp\/wp-content\/uploads\/2020\/05\/Figure2-1024x718.png 1024w, https:\/\/www.genome.rcast.u-tokyo.ac.jp\/wp-content\/uploads\/2020\/05\/Figure2-768x539.png 768w\" sizes=\"auto, (max-width: 1236px) 100vw, 1236px\" \/><\/a><br>\r\n<div class=\"layoutArea\">\r\n<div class=\"column\">\r\n<p>\u56f3 2:\u98f2\u9152\u30fb\u55ab\u7159\u7fd2\u6163\u3068\u300c\u30b7\u30b0\u30cd\u30c1\u30e3 16\u300d\u30b2\u30ce\u30e0\u5909\u7570\u30d1\u30bf\u30fc\u30f3\u306e\u95a2\u9023\u6027\u306e\u89e3\u6790(\u65e5\u672c\u4eba\u80c3\u304c \u3093 243 \u75c7\u4f8b\u306e\u30b2\u30ce\u30e0\u89e3\u6790\u306e\u7d50\u679c)<\/p>\r\n<\/div>\r\n<\/div>\r\n<a href=\"https:\/\/www.genome.rcast.u-tokyo.ac.jp\/wp-content\/uploads\/2020\/05\/Figure3.png\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-4205\" src=\"https:\/\/www.genome.rcast.u-tokyo.ac.jp\/wp-content\/uploads\/2020\/05\/Figure3.png\" alt=\"\" width=\"1566\" height=\"796\" srcset=\"https:\/\/www.genome.rcast.u-tokyo.ac.jp\/wp-content\/uploads\/2020\/05\/Figure3.png 1566w, https:\/\/www.genome.rcast.u-tokyo.ac.jp\/wp-content\/uploads\/2020\/05\/Figure3-300x152.png 300w, https:\/\/www.genome.rcast.u-tokyo.ac.jp\/wp-content\/uploads\/2020\/05\/Figure3-1024x521.png 1024w, https:\/\/www.genome.rcast.u-tokyo.ac.jp\/wp-content\/uploads\/2020\/05\/Figure3-768x390.png 768w, https:\/\/www.genome.rcast.u-tokyo.ac.jp\/wp-content\/uploads\/2020\/05\/Figure3-1536x781.png 1536w\" sizes=\"auto, (max-width: 1566px) 100vw, 1566px\" \/><\/a><br>\r\n<div class=\"layoutArea\">\r\n<div class=\"column\">\r\n<p>\u56f3 3:\u80c3\u304c\u3093\u60a3\u8005\u306e E-\u30ab\u30c9\u30d8\u30ea\u30f3\u907a\u4f1d\u5b50\u306b\u307f\u3089\u308c\u305f\u80da\u7d30\u80de\u30d0\u30ea\u30a2\u30f3\u30c8\u3002\u65e5\u672c\u4eba\u3067\u898b\u3089\u308c\u305f\u30ec \u30a2\u30d0\u30ea\u30a2\u30f3\u30c8(\u8d64)\u3092\u6301\u3064\u80c3\u304c\u3093\u75c7\u4f8b\u3067\u306f\u3073\u307e\u3093\u578b\u80c3\u304c\u3093(\u9ed2\u67a0)\u304c\u591a\u3044\u3053\u3068\u304c\u308f\u304b\u308b\u3002<\/p>\r\n<\/div>\r\n<\/div>\r\n<\/div>","protected":false},"excerpt":{"rendered":"<p>\u767a\u8868\u8005 \u9234\u6728 \u7ae0\u6d69 (\u6771\u4eac\u5927\u5b66\u5148\u7aef\u79d1\u5b66\u6280\u8853\u7814\u7a76\u30bb\u30f3\u30bf\u30fc \u535a\u58eb\u8ab2\u7a0b\u5927\u5b66\u9662\u751f(\u7814\u7a76\u5f53\u6642\u3001\u6307\u5c0e\u59d4\u8a17)) \u6cb9\u8c37 \u6d69\u5e78 (\u6771\u4eac\u5927\u5b66\u5148\u7aef\u79d1\u5b66\u6280\u8853\u7814\u7a76\u30bb\u30f3\u30bf\u30fc \u30b2\u30ce\u30e0\u30b5\u30a4\u30a8\u30f3\u30b9\u5206\u91ce \u6559\u6388)\u52a0\u85e4 \u6d0b\u4eba(\u6771\u4eac\u5927\u5b66\u5927\u5b66\u9662\u533b\u5b66\u7cfb\u7814\u7a76\u79d1 \u885b\u751f\u5b66 &hellip; <a href=\"https:\/\/www.genome.rcast.u-tokyo.ac.jp\/en\/%e6%97%a5%e6%9c%ac%e4%ba%ba%e3%81%ae%e8%83%83%e3%81%8c%e3%82%93%e3%83%aa%e3%82%b9%e3%82%af%e3%81%a8%e3%81%aa%e3%82%8b%e9%81%ba%e4%bc%9d%e7%9a%84%e8%83%8c%e6%99%af%e3%81%a8%e7%94%9f%e6%b4%bb%e7%bf%92\/\">Continue reading <span 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